Their expression varied with respect to different astroglial subpopulations (GluT and GluR cells) of the mouse hippocampus. Finally, the highly ordered structure of the hippocampus and its significant capacity for reinnervation makes the hippocampus a favorite experimental model for the analysis of operational principles of neuronal circuitry and for the study of brain plasticity and regenerative capacity. The rodent hippocampus is com- monly divided into several subregions: Cornu amonis (CA)1, CA3, dentate gyrus (DG), and the hilus (21 Figure 1). CPEBs (2, 3 and 4) were detected in distinct astroglial subpopulations of mouse hippocampus by immunofluorescence, single cell RT-PCR and nonradioactive in situ hybridisation (ISH). Anatomy of Parts that Defines Hippocampal Function The general function of the hippocampus is to encode new information or memories, without it we wouldn’t be able to learn. In particular, the hippocampal formation as compared with other brain structures has the most protracted span of neurogenesis, which gives an opportunity not only to study certain stages of neurogenesis in detail but to investigate them experimentally using various effects. C,E: The same coronal section as in A showing channels for (in C) TBR2 (blue), Ki67 (magenta), or (in E) TBR2, Ki67 and DCX (green). Dissected human hippocampus next to a specimen of hippocampus leria, one. B: A schematic showing the dividing (Ki67 +ve) cell types in the adult hippocampus. Being a relatively simple part of the cerebral cortex with respect to its internal structure, the hippocampal formation contains various subregions with different organization and rates of development. A: Coronal section of an adult mouse brain at the level of the hippocampus stained for DAPI (white). Such interest in the hippocampus is caused both by its functional role, which is believed to be learning and memory, and by unique peculiarities of the hippocampal organization and development (see reviews in the two-volumed book edited by Isaacson and Pribram 1975, 1985). The hippocampus is one of the most intensely studied formations of the brain.
Advances in Anatomy Embryology and Cell Biologyīook series (ADVSANAT, volume 122) Zusammenfassung The hippocampus modulates a number of modules including memory consolidation, spatial navigation, temporal processing and emotion.